BIO MEDICAL RESEARCH

CMDN and INPL have been involved in conducting various biomedical research on prevalent diseases of Nepal since our inception. INPL was the first private entity to introduce HIV viral load in Nepal, providing one of the major disease progression monitoring services in the country. Hepatitis, leprosy, tuberculosis and malaria have been some of the other diseases that we have, or continue to carry out, research on. CMDN assisted Nepal Health Research Council (MoHP/GoN) carried out the landmark Human Papilloma Virus (HPV), in cervical carcinoma cases in Nepal.

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Study of HPV genotypic status in reproductive age women in Nepal

Cervical cancer is the second most common cancer and a leading cause of cancer mortality among women worldwide. According to World Health Organization (WHO), the incidence of cervical cancer in Nepal is 24.2 per 100,000, making Nepal a country with one of the highest rates of cervical cancer in the world.

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HCV infected

Validation of Interferon and Ribavirin based therapy on HCV infected people in Nepal

Hepatitis C virus (HCV) is a global health concerns with approximately 185 million chronic infections and estimated 350,000 annual mortalities. It is estimated that over 100,000...

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Poliovirus vaccine inactivation effectiveness assessment using molecular technique

Poliomyelitis is an acute paralytic disease caused by the poliovirus- a Human Enterovirus C (HEV) of the Picornaviridae family, which is classified into three distinct and stable serotypes: Sabin 1, 2 and 3.

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Newborn Care

Improving maternal and newborn care

Our study examines effectiveness of mentors in capacity development for maternal and newborn care (MNC) in Nepal. Evidence from Africa indicates that clinical mentors are effective in improving the quality of care provided by rural health workers...

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Reproductive Health

Prevalence Study of Reproductive Health morbidities in Nepal

Through the support of the Family Health Division (FHD) and technical and financial support from UNFPA, camp based prevalence of reproductive health morbidities among women was carried out by CMDN. In developing countries like Nepal the reproductive health morbidities are high and...

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Tuberculosis

PCR based molecular detection of M. tuberculosis

A pilot study carried out in 2009 with suspected TB patients from the National Tuberculosis Center Nepal, showed that molecular method of TB detection is much more sensetive (about 7% more) than the traditional AFB microscopy. This study...

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Papilloma Virus (HPV)

Prevalent Human Papilloma Virus (HPV) subtypes in Nepal

CMDN/INPL in collaboration with Nepal Health Research Council carried out prospective longitudinal study in 2010/2011 among histological confirmed invasive cervical cancer cases. Genotypes of HPV were identified using...

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Vibrio cholera

Source and Transmission of Vibiro cholera causing Cholera in Nepal

Cholera, an acute diarrheal disease caused by toxigenic strains of Vibrio cholerae, remains major killer disease world-wide. Though being absolutely preventive and curable disease, significant...

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HIV

HIV-1 Circulating Recombinant Form in Nepal

Presence of HIV-1 subtype C in Nepal was reported in 2000 (Oelrichsetal). No sub-typing data have been reported since then. There is a possibility that new viral strains may have been introduced into the Nepali population. Results from studies carried out by CMDN/INPL and Aga Khan University (Pakistan) showed a likelihood of HIV transmission from Thailand. The amplified products from the subtype analysis were deposited into the National Center for Biotechnology Information (NCBI). The study was published in Journal of Virology (2010).

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Cancer tele-diagnosis capacity building

Anecdotal evidence suggests that there is growingcancer incidence in Nepal. Nepal ranks 9th and 10thon oral and ovarian cancer respectively (World LifeExpectancy, 2012). Certainly the burden of cancer tonational healthcare is exasperated by lack of adequatehospitals, but more importantly the front and center ofcancer treatment-diagnosis, is not only limited in Nepal,majority of pathologists are not well versed in morespecific differential diagnosis of cancer

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One Health in Nepal

One Health Concept emphasizes on multidisciplinary approachto study disease dynamics interlinking wildlife, environment,livestock and human health with multiple disciplines workingtogether (locally, nationally and globally) to achieve optimalhealth for all.

The rapid speed at which zoonotic pathogens can potentiallyemerge and spread from animals to people could pose seriousthreat to public health and economy. Majority of these diseasesoriginated

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Viral Disease Detection to Aid in Vaccination Planning for Nepal’s Pig Industry

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) cause fatal diseases in pigs, resulting in major economic loss for the industry. Two different types of PRRSV are currently known. Intrepid Nepal Pvt. Ltd. (INPL) has been using real-time PCR based screening technology to properly identify and characterize the viral strains of PRRSV in affected pigs in Nepal...

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Developing Highly Effective and Thermo-tolerant Vaccines to Tackle Poultry Disease

Polio is believed to be eradicated in Nepal. However, biomedical waste arising from the polio vaccines used to prevent the disease need to be properly disposed of if we are to prevent this disease from re-emerging. The polio vaccine uses an attenuated (not capable of causing disease) form of the virus, but it is capable of mutating and reverting back to its virulent form. Similar genetic makeups of the attenuated and wild-type viruses make them indistinguishable from each other.

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Highly Efficacious Treatment for Hepatitis C Virus (HCV) by Disrupting its Replication

A more thorough understanding of HCV has led to the development of treatment like Direct Acting Antiviral (DAA), which targets specific non-structural proteins in the virus and disrupts its replicating and infecting capabilities. Compared to existing remedies, DAA-based treatments provide a higher cure rate, fewer side effects, and reduce the length of therapy by up to four times. A major challenge to this treatment are HCV patients that are also affected by HIV and/or those who have a history of alcohol and drug abuse.

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Implementing Measures for the Prevention of Antimicrobial Resistant (AMR) ‘Superbugs’ – at a Local and National Level

The emergence of ‘superbugs’ or AMR bacteria is becoming a major concern in Nepal. Understanding AMR through rigorous surveys and analyses has become very important, as the threat to animals and humans has been increasing. CMDN is building a genetic-based AMR profiling, including building capacities to detect and screen a broad spectrum of AMR bacteria. This will aid in comparative....

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