HPV infection is the most common sexually transmitted viral infection in humans. More than 100 types of HPVs have been identified, among which around 15 are categorized as “high-risk” viruses that can lead to cervical cancer. Cervical cancer is the leading cause of deaths related to cancer among women of reproductive age in Nepal – with up to 2000 deaths per year due to the disease. Our HPV study is a pilot study for HPV prevalence, screening and viral genotyping, together with assessment of reproductive health awareness in urban slums of Kathmandu, Nepal. With this study we plan on providing a baseline data on the prevalence of HPV infection in poor urban communities that could inform the government and healthcare system on effective implementation of our national cervical cancer screening program.